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FDA-approved GLP-1 receptor agonists include semaglutide (Ozempic, Wegovy, Rybelsus), dulaglutide (Trulicity), liraglutide (Victoza, Saxenda), lixisenatide (Adlyxin), exenatide (Bydureon BCise), and tirzepatide (Mounjaro, Zepbound)though tirzepatide is technically a dual GIP/GLP-1 receptor agonist
While convenient, these blends make dosing control difficult and may mask impurities in one component
This paper reports the cryo-electron microscopy structure of the GSDMD pore and reveals its charge-based selectivity for releasing mature IL-1
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