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Oral semaglutide reduced major adverse cardiovascular events by 14% compared to placebo (hazard ratio 0.86, 95% CI 0.77-0.96)
Higher doses are usually split into two servingsone in the morning and one in the eveningto keep levels steady in the bloodstream
It has been shown that Exendin-4 (A GLP1R agonist) can improve glycemic levels, even in T1DM patients who do not have any residual beta cells (Dupr et al , 2004)
Monitoring blood glucose levels is paramount, particularly for patients on combination therapy with insulin or sulphonylureas
Data are presented as mean + s.e.m
However, combining these medications should be done under strict medical supervision to avoid potential risks such as hypoglycemia, where blood sugar levels drop too low
