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A Phase 1 healthy-volunteer study later confirmed rapid absorption, a 67-day half-life, and a favorable tolerability profile [Nature Communications]
La Rosa C, Parolisi R, Bonfanti L
This study was submitted for evaluation by the Ethics Committee on the Use of Animals (CEUA) of UNESC under protocol number 07/2023
GLP-1 drugs can cause gastrointestinal side-effects such as nausea, vomiting, diarrhoea and constipation
10.1186/s41232-018-0070-0 49 WangW
For example, the SELECT trial reported that semaglutide reduced the risk of MACE by 20% (Hazard Ratio (HR) 0.80, 95% confidence interval (CI) 0.720.90) in people with obesity but without diabetes, although several secondary outcomes did not reach statistical significance under hierarchical testing procedures
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