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Probing binding requirements of NAD kinase with modified substrate (NAD) analogues

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A recent study has shown that bitter taste receptors are utilized in the treatment of humans, namely in the NCI-H716 cell line

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Atsmon J, Dolev E

Although biochemically separated from the GSH system, the Trx system shares NADPH as a common reducing cofactor and serves as an alternative pathway for reducing disulfide bonds, making this system especially relevant if the GSH system has been compromised or rendered dysfunctional (Silva-Adaya et al., 2014)