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The magnitude differs

10.1016/j.bbrc.2011.05.155 47 FarkasG.KirlyZ.SolymosiF

Largest trial reported increased risk and persistence of CIPN with prophylactic use

Effect: Enhance insulin secretion, suppress glucagon, delay gastric emptying, and promote weight loss

Unlike the combinatorial therapy of G-protein-coupled receptor-based peptide dual agonists, such as GLP-1/glucagon, these peptidyl nuclear hormone conjugates require additional consideration for differential pharmacodynamics where time action for clearance of each activity is inherently dissimilar