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(Left) In liver cells, GLP-1 can mediate cholesterol efflux by acting directly on LXR, or by inducing an increase in ATP-binding cassette transporter A1 (ABCA1) mRNA through Ca2+/calmodulin (CaM)-dependent protein kinase kinase/CAM-dependent protein kinase IV/Prolactin regulatory element binding (CaMKK/CaMKIV/PREB), increasing apolipoprotein AI (apo AI) mRNA and promoter expression, and increasing apo AI secretion, thereby mediating intracellular cholesterol efflux

AstraZenecas GLP-1 pill, elecoglipron, which in phase II trials showed clinically meaningful weight loss of up to 10.5% at 26 weeks and 11.8% at 36 weeks in the highest-dose groups of adults without diabetes 21

Secondly, the cross-linking structure of the polymer network plays a crucial role

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