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[12] [13] Pharmacologically, semaglutide is a GLP-1 receptor agonist, while tirzepatide is a dual GIP/GLP-1 receptor agonist

Whether retatrutide's glucagon receptor agonism provides additive cardiovascular benefit beyond what GLP-1 and GIP activation deliver is an important question that dedicated cardiovascular outcomes trials (CVOTs) within the TRIUMPH program may eventually answer

Screening and monitoring Recommendations for patients starting or currently on GLP-1 medication would be to have a baseline dilated fundoscopy, followed by annual retinal exams to monitor any irregularities in patients

You need to know what to monitor, when to worry, and what conversations to have with your prescriber

The clinician evaluates your complete health picture and recommends what may be appropriate

Evidence shows most birth control methods, aside from the Depo-Provera shot, do not cause clinically significant weight gain, Thomas said