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Mutations in the genes encoding estrogen hormone, ESR1 , are associated with acquired resistance (intrinsic or extrinsic) to endocrine therapies (59)

PMID 33084757 Jiang J, et al

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These findings reinforce the value of multimodal baseline profiling, integrating biochemical and retinal imaging biomarkers, to identify patients at higher risk of early disability progression and to support more personalized management strategies in MS

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