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6 Gut microbiota dysbiosis and cytokine abnormalities 6.1 Evidence for the association between cytokines and schizophrenia Given the dysfunction of the BBB in patients with schizophrenia, changes in cytokine levels in the periphery (peripheral blood) and the center (cerebrospinal fluid, CSF) are valuable for assessing the CNS inflammatory state
These include regulation of mechanisms controlling reactive oxygen species (ROS), which cause macromolecular damage 16,17 , mitochondrial turnover or mitophagy 18 , and the mitochondrial unfolded protein response (UPR mt ), in which mitochondrial damage can be prevented by the removal of aggregated or unfolded proteins 19
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Dopamine and alcohol dependence: from bench to clinic
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