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Key differences in tirzepatide vs semaglutide mechanism of action relevant to drug design are: Clinical comparisons between tirzepatide and the more balanced RG7697, whose efficacy approximated liraglutide, confirm that receptor activity ratio and signaling bias are as consequential as dual engagement itself

Devesa J, Almenglo C, Devesa P

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Currently, there is no evidence to support using GLP-1 agonists as a primary replacement for standard immunosuppressive therapy

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I recommend taking it in liquid form, if possible, and finding supplements that are lypo-spheric, or fat soluble