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Its important to remember that these side effects are often mild and improve over time

Food and Drug Administration (FDA) and the Central Drugs Standard Control Organisation (CDSCO) in India, have approved GLP-1 RAs based on their safety and efficacy 3 , 6

For a plain-language overview of why this buildup happens with weekly dosing, see Medical News Todays explainer

These neurons either express the neurotransmitter norepinephrine (NE) or the neuropeptide CCK and are monosynaptically connected to calcitonin generegulated peptide (CGRP)-expressing neurons in the lateral parabrachial nucleus (lPBN) of the pons [61], which are in turn monosynaptically connected to protein kinase C (PKC)-delta-expressing neurons in the central nucleus of the amygdala (CeA) in the forebrain [62, 63], thus forming a tripartite functional unit

However, excessive accumulation triggers oxidative stress, leading to oxidative damage that disrupts protein structure and function, ultimately inducing cell death

The highest dose of the drug (25 mg) will cost $299 a month for self-pay customers