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The Phase 3 TRIUMPH-4 trial (NCT05869903) enrolled adults with obesity and knee osteoarthritis

Studies suggest that B12 deficiency may contribute to the development of dementia and Alzheimers disease

ID, AK, HZ, and MK: validation

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A search on PubMed returns many papers on rodents and cell models, and reviews on PubMed Central describe it as a possible therapy rather than a proven one

Despite the absence of a statistically significant doseresponse relationship observed in this analysis, clinical decision-making should consider that absorption efficiencyrather than absolute dosagemay be the limiting factor