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The downregulation of OCTN2 activity and protein expression in the kidney reduces the reabsorption of carnitine in the kidney, leading to a decrease in carnitine availability in the liver and causing hepatic lipid metabolism disorders [260]
This was a collagen-production study not a broad wrinkle-reduction trial so the scope matters
A vital factor in these patients is iron overload, although when present, it can be effectively managed by chelation therapy (Berdoukas 2012)
In 2008, this lab reported that an additional complex RAS synthetic lethal 3 (RSL3) induced a similar cell death form, which could be inhibited by iron chelates (Yang and Stockwell, 2008)
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