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For example, Y182 1.43b is reoriented ~90 from an outside facing position to a position pointing to TM2 and engages T-shaped stacking with Phe 6P of GLP-2
Several key themes emerge: 1
& Buck, L.B
Compared to continued use of GLP-1s for three years, which corresponded to an 18% risk reduction, GLP-1 users who experienced interruption and subsequently resumed gained a 12% risk reduction on average
The efficacy of the new pharmacotherapies will allow clinicians to treat obesity towards individualised treatment targets, similar to what is happening with other chronic diseases such as T2D or dyslipidaemia
Evidence level: Level A (non-listing) plus plausibility only
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