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A simple mistake in calculating concentration means every subsequent dose is wrong

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If left untreated, it can lead to an increased risk of serious health problems, including permanent nerve damage

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Oral administration at 100150mg to match subcutaneous bioavailability doubles the per-dose cost, which influences protocol design when budget constraints exist

Sublingual preparations are available, though evidence for their superiority over standard oral tablets is limited, and they are not routinely recommended in UK clinical practice