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We next explored the effect of combination treatment with TRAIL and BPTES, an inhibitor of glutaminase, a key enzyme in Gln metabolism, in vitro as well as in vivo in an orthotopic pancreatic tumor mouse model
Renal outcomes Eleven meta-analyses (17 outcomes) evaluated GLP-1 RAs for renal outcomes (Fig
-Glutamyl transpeptidase (GCLC) deficiency has been found in patients with CNS involvement and glutathionuria
The STEP-HFpEF trial randomised 529 patients with obesity (BMI 30 kg/m 2 ), HFpEF (left ventricular ejection fraction [LVEF] 45%) and New York Heart Association (NYHA) Class II symptoms to once-weekly subcutaneous semaglutide 2.4 mg or placebo
Sustainable weight management requires long-term commitment to healthy eating patterns and regular physical activity rather than quick-fix solutions lacking robust scientific support
