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Polypodium leucotomos (fern) extract has been the subject of some research examining its antioxidant properties in relation to UV exposure

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Neuropsychopharmacology 2008, 33(9):21872199

Instead, it is designed solely to activate the innate repair receptor (IRR) , the bodys primary switch for tissue protection and anti-inflammation.According to research published in Molecular Pain , ARA-290 is disease-modifying. It works by quieting microglia , the immune cells in the nervous system that drive chronic pain when overactive

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Intriguingly, other studies report no change in fibroblast responsiveness with age [165]