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Now this is understood, paraxanthine isn't showing these differences across individuals

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doi:10 } : CS1 maint: multiple names: authors list (link) "Peptides Regulating Proliferative Activity and Inflammatory Pathways in the Monocyte/Macrophage THP-1 Cell Line"

Gilmour MI, Jaakkola MS, London SJ, Nel AE, Rogers CA: How exposure to environmental tobacco smoke, outdoor air pollutants, and increased pollen burdens influences the incidence of asthma

Am J Clni Nutr 2011

In Vitro Evidences for Ethanol-Inducible CYP2E1 and ADH Activity Several in vitro models have been established to study the adverse effects of ADH and CYP2E1 in liver cells