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In order to rule out direct glucose effects on the macro- and microvascular event rate, glucose parameters are kept as closely overlapping as possible (5456)

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The Arg3 substitution and N-terminal 13-residue extension in IGF-1 LR3 reduce IGFBP affinity by approximately 1,000-fold, preventing this sequestration

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Timeline and Prevalence of GLP-1 Gastrointestinal Side Effects Gastrointestinal side effects from GLP-1 therapy are common but often temporary

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