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doi: 10.1016/S0167-0115(01)00300-7 159 FandioJVazAATobaLRoman-PrezMGonzlez-MatasLMalloFet al

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Data has indicated significant use of tramadol in sports and research studies funded by WADA have confirmed the potential for tramadol to enhance physical performance, in addition to its potential to adversely affect athlete health due to its opioid properties

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This third target is associated with increased energy expenditure in addition to the appetite suppression and satiety signalling produced by GLP-1 and GIP receptor activity, which researchers believe is responsible for the compounds exceptionally large weight-loss signal in clinical trials