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Notably, RSL3 is widely used as a pharmacological inhibitor of GPX4, although studies in cell-free systems suggest that it may also exhibit inhibitory activity toward thioredoxin reductase 1 (TXNRD1), a key NADPH-dependent antioxidant enzyme that maintains thioredoxin-mediated redox homeostasis

It is not approved, intended, or labelled for use in humans or animals

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For Healthcare Professionals Berberine is an alkaloid constituent active in a number of plant species including barberry ( Berberis vulgaris ), Chinese goldthread ( Coptis chinensis ), goldenseal ( Hydrastis canadensis ), tree turmeric ( Berberis aristata ), and Oregon grape ( Berberis aquifolium ) (1)

It is important to follow simple precautions and guidelines to avoid unwanted effects and maintain a healthy balance