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Tolerance has not been observed in clinical use

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In the stage I trial, Bioglutid reduced fasting blood glucose by 1.8 mmol/L and glycosylated hemoglobin (HbA1c) by 0.9% in patients with type 2 diabetes, which was better than the single target GLP-1 analog

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7 Therefore, building on these observations, Dr Braca and colleagues hypothesised that exploiting the same mechanism of action might ultimately dampen cortical and trigeminal sensitisation that underlie migraine