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When that barrier gets irritated, immune cells react

Hanif M, Hays AG, Nagarajan JS, Sah SP, Weinstock RS, Taub CC

PMID 38520069

Even though, considering the essentiality of copper in humans, the copper hypothesis of GHK mechanism of action seems very attractive, recent gene data may challenge this mechanism and demand more studies into GHKs mechanism of action

The mechanisms underlying these effects involve mesenchymal stem cell proliferation and directed migration to injury sites, periosteum reactivation initiating new bone formation at attachment points, nitric oxide pathway modulation enhancing vascular tone and blood supply, and cytoprotective effects reducing tissue necrosis during the critical early inflammatory phase