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Side Effects: Hydroxocobalamin has been used for decades and it has a long and proven safety record with very few reports of side effects affecting patients
This is why week 1 tolerance is a poor predictor of week 5 tolerance, and why the trial ladder holds each step for a full 4 weeks rather than 1 or 2
It's about a methodology
Manchikanti, L., Cash, K
To overcome this limitation, research efforts have been devoted to the development of therapeutic agents with biological mechanisms of action that are independent of the oxygen concentration
Compare compound name, molecular identity, and sequence context across records
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