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Gln depletion therapy can inhibit Gln metabolism in tumor cells, but in colon cancer, it has been observed that Gln depletion promotes the expression of the aspartate/glutamate transporter SLC1A3 in tumor cells, increasing the intracellular glutamate concentration and promotes Gln synthesis
increase by 100250 mcg increments every 12 weeks as tolerated [2]
J Pediatr 1991;118:6469
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