Pre-clinical studies showed that anti-atherogenic effect of GLP-1 is independent of modulation of plasma lipid levels and depends on anti-inflammatory response
Aim to use at least two herbs or spices per meal, especially with protein- and fiber-rich foods
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Considering the potential of secondary bile acids to increase L-cells and GLP-1 secretion by TGR5, TGR5 agonists are promising drug candidates for increasing L-cells and GLP-1 secretion [180, 181]
And while most of these compounds start off being tested and approved for type-2 diabetes, and later are tested and approved specifically for obesity, that order may be changing
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