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Most people are surprised at how simple and painless the process actually is once they try it for the first time

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In particular, G6PD is essential in preserving the integrity of erythrocytes because, lacking mitochondria, they have no other NADPH-generating enzymes to protect against oxidative stress 2

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10.1016/0024-3205(93)90589-u 19 SikiricP.SeiwerthS.RucmanR.KolencD.VuleticL

However, the electrons of NADPH are destined for use in reductive biosynthesis, rather than for transfer to oxygen as is the case with NADH