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Tirzepatide uses the highest absolute doses (2.5mg starting, up to 15mg maintenance) because its dual-agonist design has moderate potency at each individual receptor
Additionally, McConkey et al., in 1967, observed the occurrence of transparent skin that was associated with a decrease in dermal collagen in postmenopausal women [21]
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They can also alleviate the vascular remodeling after induced vascular injury by suppressing vascular smooth muscle cell proliferation and migration via the cAMP/PKA pathway
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