Recombinant Human Nephroblastoma-overexpressed Gene Protein Homolog (Human NOV) _ C230451 Other growth factors is a member of the

is a member of the IL-1 family which includes IL-1 beta

The protein has a predicted MW of 54

and 98% homology with mouse/dog/horse

It may be the main paracrine factor for the proliferation of normal epithelial cells

EIRNTEDLTE EWLREKLGFF H

Recombinant Human Nephroblastoma-overexpressed Gene Protein Homolog (Human NOV) _ C230451 Other growth factors is a member of theNOV is a member of the CCN family of secreted, cysteine rich regulatory proteins. The full length NOV protein contains four structural domains that confer distinct, and sometimes opposing, biological activities. Elevated expression of NOV is associated with certain tumors, including Wilms tumor and most nephroblastomas. However, in other tumor types and certain cancer cell lines, increased tumorigenicity and proliferation is correlated with decreased