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The report also noted that a large Phase IIb trial (ZUPREME-1) is underway with enrolment expected to be completed in the first half of 2025 and that a second Phase IIb trial (ZUPREME-2) is planned to evaluate petrelintide in individuals with type 2 diabetes

Int J Fertil Steril

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Origin and functions of tissue macrophages

Small-molecule agonists may differ from peptide ligands in receptor residence time, signaling persistence, and potential off-target interactions, which can influence experimental outcomes [3]