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Although the reasons for the lack of difference in circulating leptin levels in animals with different degrees of adiposity are unknown, it is possible to speculate that changes in autonomic innervation or hormonal milieu could have affected leptin synthesis and secretion by adipose tissue

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"The development of small molecule angiotensin IV analogs to treat Alzheimer's and Parkinson's diseases." Progress in Neurobiology

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The complexity of neurosteroid-mediated effects, for instance gating of GABA A R (109, 135139) and subunit-specific modulation of glycine and NMDARs (140), suggest the likelihood of multiple binding sites that contribute to potentiating and inhibitory effects ( A Rs also appears to involve modulation of subunit-containing receptors which play a role in tonic inhibition (141145)

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