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It has, in many ways, become a real-time experiment happening in each individual body

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PubMed 8688086 Cunha SR, Mayo KE

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Briefly, two main complexes operate during NHEJ: 1/ DNA-dependent protein kinase (DNA-PK) recognizes, protects and brings DSB ends closer and, via its auto-phosphorylation, promotes loading and activation of processing factors necessary to clean the ends before ligation