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These conditions may affect L-cell populations and function
By targeting GLP-1 receptors in the brain and pancreas, these medications effectively reduce appetite, increase satiety, and improve insulin sensitivity, which can contribute to significant weight loss
Senolytics , drugs that clear the worn-out senescent cells that accumulate with age, are the more serious candidate
Some women have become unexpectedly pregnant while on GLP-1 medications
In terms of onset, the oral form may take slightly longer to produce noticeable effects because of its lower and more variable bioavailability
But as these medications become the standard of care for obesity, an important question is emerging from the orthopedic and musculoskeletal literature: what happens to bone density and lean muscle mass during rapid, pharmacologically driven weight loss
