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PMID 20122128
Although clinical studies have not demonstrated overt systemic depletion of NAD(P) during GLP-1RA therapy, sustained reductions in nutrient inflow may influence precursor availability and turnover kinetics, particularly in metabolically stressed populations
Zeng H, Song J, Li Y, Guo C, Zhang Y, Yin T, et al
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[3] Some preclinical studies suggest GLP-1 may have beneficial effects on pancreatic beta cells, though long-term preservation of function in humans remains unproven
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