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Pharmacological hypothesis: A recombinant probiotic for taming bacterial beta-glucuronidase in drug-induced enteropathy

See Table 3 in the Appendix for further details on ICD- and ATC-codes

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Whilst some laboratory studies and small-scale human trials have suggested that certain probiotic strains may influence gut hormone levels, there is currently no robust clinical evidence demonstrating that probiotic supplements can reliably increase GLP-1 production or lead to clinically significant weight loss in humans

Several recent CVOTs have shown that GLP-1RAs can reduce the decline of estimated GFR (eGFR) and delay the onset of the occurrence of proteinuria in patients with T2DM [4, 22, 26, 46, 47]