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7.4.4 Next-generation agonists The development of dual GLP-1/GIP receptor agonists (e.g., tirzepatide) and novel blood-brain barrier-penetrant formulations may offer superior neuroprotective efficacy by more potently engaging central receptors or providing a broader spectrum of action ( 7.5 Limitations of current evidence Several limitations must be considered when interpreting the current evidence

Folli F, Guardado MR