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BMC Palliat Care
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Because sample sizes in individual studies were small, single studies were not considered a sufficient and reliable evidence base from which to construct an evidence-based statement (i.e., a Standard, Recommendation, or Option)
100 In addition, a high-fat diet and short-chain fatty acids (the metabolites of the gut microbiota) can alter intestinal permeability, which is a characteristic of human T2D
Some compounders claim adding B12 to a GLP-1 may help address fatigue, particularly in people with a vitamin deficiency
The next generation of regimens may involve combining GLP-1 or dual GIP/GLP-1 receptor agonists with other nutrient-based hormone receptor agonists or antagonists that offer equal or greater effectiveness with fewer gastrointestinal adverse effects
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