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Griffith, D.A., Edmonds, D.J., Fortin, J.P., Kalgutkar, A.S., Kuzmiski, J.B., Loria, P.M., Saxena, A.R., Bagley, S.W., Buckeridge, C., Curto, J.M., Derksen, D.R., Dias, J.M., Griffor, M.C., Han, S., Jackson, V.M., Landis, M.S., Lettiere, D., Limberakis, C., Liu, Y., Mathiowetz, A.M., Patel, J.C., Piotrowski, D.W., Price, D.A., Ruggeri, R.B., Tess, D.A

Abstract Recent literature shows that GLP-1 receptor agonists are highly effective for weight loss and improving metabolic and cardiovascular health, often surpassing the results of lifestyle interventions alone, such as exercise and diet modification

moreover, l-ARG has been found to play a relevant positive impact on atherosclerosis, as demonstrated by two RCTs showing that administration of l-ARG improved endothelium-dependent vasodilation of brachial [55] and coronary arteries [56] in patients with angiographically reported coronary artery disease

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A 2024 study found semaglutide improved sperm morphology in obese men with type 2 diabetes and functional hypogonadism [3]