tirzepatide vs ozempic mechanism Semaglutide Tirzepatide, which is better for you? Deciding between Tirzepatide and Semaglutide

Titration: In the event that further regulation of glycemic levels is required following a minimum of four weeks at the 0.5mg dosage, consider escalating the dose to 1mg weekly

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Key outcomes: Mean weight loss: 14.9% (vs 2.4% placebo) 86.4% of participants achieved 5% loss (vs 31.5% placebo) 50.5% achieved 15% loss (vs 4.9% placebo) SELECT (Lincoff et al., NEJM 2023) added the cardiovascular signature: in 17,604 non-diabetic adults with prior CV history, semaglutide 2.4 mg reduced MACE (CV death, MI, stroke) by 20% over 3 years

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While these effects are usually temporary and improve as the body adjusts to the medication, its important to monitor changes and discuss persistent issues with a healthcare provider for medical advice

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