Schwartz MW, Woods SC, Porte D Jr, Seeley RJ, Baskin DG
Interestingly, reproductive responses were partially different in the PCOS model of preserved ovulation, since treatment of PNA mice with a low dose of GLP1/E was capable to elevate LH levels and reversed, to a large extent, the ovarian cycle irregularities observed in PNA mice treated with vehicle
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thus, the phenotype is manifest fully in males whereas female heterozygotes display varying degrees of G6PD deficiency, due to alternate X-chromosome inactivation 3,4
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