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The SURPASS-2 trial compared tirzepatide with semaglutide 1 mg weekly, showing that tirzepatide achieved HbA1c reductions of 2.01%, 2.24%, and 2.30% at doses of 5 mg, 10 mg, and 15 mg respectively, versus 1.86% with semaglutide

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Glucagon-like peptide-1 (GLP-1) receptor agonists are a class of medications with specific UK licences: some are approved for type 2 diabetes management (semaglutide [Ozempic], dulaglutide [Trulicity], liraglutide [Victoza]), while others are specifically licensed for weight management in adults with obesity or overweight with weight-related comorbidities (semaglutide [Wegovy], liraglutide [Saxenda])