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Lastly, patients with persistent AF have more underlying diseases, such as coronary heart disease, hypertension, and cardiac insufficiency, which will affect the results of TMAO

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Carnitine is an essential amino acid and it cannot be produced in the body

Therefore, we sought a less-sensitive functional assay with reduced receptor expression levels to enable the optimization of efficacy-driven GLP-1R agonists for clinical development

This effect appeared to be mediated by antioxidant mechanisms involving GSK3 phosphorylation 156 , and it was also associated with a reduction of measures of memory impairment in mice 157

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