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In the United States, 42.4% of adults meet obesity clinical criteria, while only 2.3% of eligible patients currently receive prescription anti-obesity medication
In recent years, the therapeutic footprint of this class has grown: long-acting agents (e.g., liraglutide, semaglutide) and next-generation dual/triple agonists (e.g., tirzepatide) have demonstrated superior glycemic control, weight reduction, and cardiovascular benefits in adults with T2DM (Yao et al., 2024)
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This variation in treatment effect is suspected to be due to differences in medications, differences in methodology for lean mass assessment, and different lifestyle interventions prescribed in combination with pharmacological therapies [71]
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Several studies have shown that inulin supplementation in mice during gestation or lactation induced the growth of beneficial bacteria in the intestine of maternal mice
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