glp 1 and acid reflux For patients taking GLP-1 receptor agonists (GLP-1 RAs), the use of proton pump inhibitors (PPIs) is associated with an increased risk for gastrointestinal (GI) adverse effects, according to research presented at the Experiencing heartburn while on GLP-1s?

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This selectivity is a key reason why it's considered to have a favorable side effect profile

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Inhibiting alpha-glucosidase reduces the amount of simple sugars available for absorption, mitigating postprandial glucose surges (Tundis 2010)

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