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Although mutation of C438 did not alter the PAM activity of BETP or compound 2 (Ref 27 ), it cannot rule out possible formation of a covalent adduct at C438 in our compound 2-bound GLP-1R structure
Side effects can also occur, such as: Abdominal pain Nausea Vomiting Diarrhea Gastroparesis (delayed stomach emptying) Pancreatitis Possible increased risk of sudden blindness Cost and insurance coverage Health insurance coverage varies widely for GLP-1 medications and can cost a patient hundreds of dollars per month
Gallbladder disease, gastroparesis, retinopathy, and other complications may require examination or imaging rather than blood testing alone
New hair growth may become noticeable in the affected areas
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In addition, GLP-1RAs, reduce pancreatic islet -cell apoptosis, stimulate the proliferation and differentiation of -cells, and decrease body weight by suppressing food intake in patients with T2DM [8, 41,42,43]
