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Osmotic laxatives such as macrogol and bulk-forming laxatives like ispaghula husk are safe for long-term use under medical supervision

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This study was conducted with reference to a previous investigation on the reproductive toxicity of PS-MPs in male mice, in which the administered dose of PS-MPs was 1 mg/day (equivalent to 33.340 mg/kg/day for mice weighing 2530 g) [40]