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Vitamin B12 Deficiency Causes Vitamin B12 comes mostly from animal foods

That changed after chemist Bruce Merrifield developed solid-phase peptide synthesis, a breakthrough that earned him the Nobel Prize in 1984 and dramatically simplified production of these fragile biomolecules by allowing them to be built much more efficiently compared to purification

Practical recommendations: If you have a confirmed B12 deficiency requiring high-dose supplementation, a standalone B12 product is usually sufficient

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This nuanced position deserves attention

Cyanocobalamin: Properties and Indications Cyanocobalamin is a man-made Vitamin B12