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Knezevic M et al
Inhibiting pyroptosis with Caspase-1 inhibitor VX-765 effectively suppressed the occurrence of pyroptosis in HK-2 cells, as well as the tubular damage, renal inflammation and DKD progression in diabetic mice (168)
It combines the effects of GLP-1, GIP, and glucagon receptor activation to help reduce appetite, enhance fat burning, and improve insulin sensitivity
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