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[Accessed 9 th September 2025] Tirzepatide and health-related quality of life in adults with obesity or overweight: Results from the SURMOUNT-3 phase 3 randomized trial

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The most commonly reported side effects in Phase 2 trials include nausea, vomiting, diarrhoea, constipation, and increases in resting heart rate

The effect varies by medication, dose, and whether the drug is used for diabetes or obesity, but the overall pattern is clear

The relationship between Candida and hormonal imbalance is bidirectional: oestrogen promotes Candida adherence and proliferation, while Candida produces oestrogen-mimicking compounds (mycoestrogens) and impairs hepatic oestrogen metabolism, worsening oestrogen dominance