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In women with endometriosis, the imbalance between ROS production and antioxidant defense leads to oxidative stress [26], which promotes inflammation, contributing clinically to pain at affected lesions [24] and infertility [25]

It can increase the risk of cancer, diabetes, hepatitis, and Parkinsons disease

Statements Author contributions YY: Conceptualization, Writing review & editing, Formal Analysis, Data curation, Writing original draft

Under normal physiological conditions, nuclear factor erythroid 2-related factor 2 (Nrf2) remains sequestered in the cytoplasm through its association with Kelch-like ECH-associated protein 1 (Keap1)

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Flavonoids also inhibit the expression of adhesion molecules such as ICAM-1 and VCAM-1, which are responsible for the recruitment of leukocytes to the blood vessel wall